The Journal of Antibiotics Immunosuppressive Activity of 1 5-deoxyspergualin and Its Effect on Skin Allografts in Rats
نویسندگان
چکیده
The immunosuppressive activity of spergualin analogues, 15-deoxyspergualin and N-30, is presented. These compounds suppressed antibody formation and establishment of delayedtype hypersensitivity to sheep red blood cells (SRBC) in mice. Amongspergualin, 15-deoxyspergualin, and N-30, 1 5-deoxyspergualin was most effective in suppressing immuneresponses. It suppressed antibody formation against SRBCby spleen cell cultures in a dose-dependent fashion without reducing cell viability. The spergualins also suppressed the mixedlymphocyte culture reaction. Peritoneal exudate cells taken from mice given immunosuppressive doses of 15-deoxyspergualin were not reduced in their functions measured: Release of lysosomal enzymes and production of superoxide anions. 15-Deoxyspergualin and N-30 were markedly effective in prolonging skin graft in rats.
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